Menopause care by clinicians who actually specialize in menopause.

Nuvella is built exclusively for women.

Every part of the Nuvella experience, from the health assessment to the clinical protocols to the nurse care team, is designed specifically for women navigating perimenopause, menopause, and midlife hormonal changes. Our clinicians specialize in women's health. Our nurses understand the menopause journey at a deep level. And our treatment plans are built around what women in their 40s, 50s, and 60s are actually going through.

This isn't a general telehealth platform that added a menopause tab. This is a dedicated women's hormone health program, powered by DirectMeds, one of the largest telehealth platforms in the country.

No. Everything is done from home.

You'll start with a quick online health assessment. From there, you'll have a live, synchronous consultation with a licensed clinician in your state who specializes in women's health. This is a real conversation with a real provider. Not a chatbot, not an automated questionnaire, and not a faceless form that gets rubber-stamped.

Once your personalized treatment plan is approved, your medications are compounded at a fully licensed U.S. pharmacy and shipped directly to your door. Your nurse care team stays with you throughout the program for check-ins, questions, and adjustments.

No waiting rooms. No awkward appointments. No driving to a pharmacy. Just expert care, delivered on your terms.

Yes. Every Nuvella patient has a live, synchronous consultation with a licensed clinician in their state.

We have hundreds of clinicians across the country who specialize in women's health and hormonal care. Your provider will review your health history, discuss your symptoms, answer your questions, and build a treatment plan that's tailored to you. This is not an automated approval process.

Beyond your provider, you'll also have access to a dedicated nurse care team that specializes in menopause and HRT. They're available for questions, follow-ups, and guidance throughout your entire program. If you need a dose adjustment, have a concern about how you're feeling, or just want to talk through what's normal, your care team is a message or call away.

This is one of the biggest differences between Nuvella and other telehealth HRT providers. Many companies just want to send you meds and move on. We believe the clinical relationship is the product, not just the prescription.

Your Nuvella treatment plan is built around you, not a one-size-fits-all protocol.

During your consultation, your provider evaluates your specific symptoms, severity, health history, risk factors, medications, and personal goals. Based on that conversation, they design a protocol that may include some or all of the therapies in the Nuvella HRT Starter Kit: estradiol topical cream, progesterone capsules, vaginal estradiol, and DHEA.

But personalization doesn't stop at day one. Your program includes a structured symptom check-in at the 6 to 8 week mark where you'll rate how your symptoms have responded across seven key areas: hot flashes, night sweats, sleep quality, mood, brain fog, energy, and sexual function. Based on your responses, your provider may adjust your dosing, modify your protocol, or order blood work to guide the next phase of care. As your body changes, your plan evolves with you. That’s what makes this a program, not just a prescription.

Every woman responds differently, but here's what many patients experience:

• Weeks 1 to 2: Your body begins adjusting to your new protocol. Some women notice early changes in sleep quality and mood during this window.
• Weeks 3 to 6: Many women experience meaningful improvement in hot flashes, energy levels, and emotional balance.
• Days 60 to 90: Your provider reviews your progress, may integrate blood work, and personalizes your plan for the months ahead. This is where the full benefit of the program tends to come together.

Hormone therapy is not an overnight fix. It takes time for your body to respond and for your provider to optimize your protocol. That's exactly why Nuvella is designed as a 90-day guided program with clinical check-ins along the way, so you're never left wondering whether it's working.

Your nurse care team is available throughout this process to answer questions, set expectations, and make sure you feel supported at every stage.

We cannot guarantee specific results because every woman's body, health history, and hormonal profile is different. What we can guarantee is the quality of care you'll receive.

Your treatment is prescribed by a licensed clinician who specializes in women's health. Your medications are compounded at fully licensed U.S. pharmacies and third-party tested for purity, potency, and quality. Your program includes structured check-ins, blood work integration when needed, and a nurse care team that's with you every step of the way.

HRT is the most clinically studied and effective treatment for menopause symptoms. While individual responses vary, the vast majority of women who follow their prescribed protocol and stay engaged with their care team experience meaningful improvement in how they feel.

If you're not seeing the progress you expect, your provider will work with you to adjust your plan. That's what the program is designed for.

If you decide to stop HRT, your body will gradually return to its pre-treatment hormonal state. For many women, this means the symptoms that brought them to Nuvella in the first place (such as hot flashes, sleep disruption, mood changes, and fatigue) may return over time.

There is no medical danger in stopping HRT, but it should always be done in conversation with your provider. Depending on how long you've been on therapy and your individual health profile, your clinician may recommend tapering your doses gradually rather than stopping abruptly.

If you need to pause or cancel your Nuvella program, you can do so at any time. Medications that have already been shipped are non-refundable, but you'll still have access to the medical support and nursing care included in your program through the remainder of your 90-day cycle. We're here to support you regardless of where you are in the process.

Everything. Your Nuvella program includes:

• • Live consultation with a licensed clinician who specializes in women's health
• • Personalized HRT protocol (up to four prescription medications)
• • 90 days of medication shipped directly to your door
• • Free shipping
• • Unlimited access to the nurse care team for questions and adjustments
• • A dedicated nurse care team specialized in menopause and HRT
• • Structured symptom check-ins to track your progress
• • Blood work integration at no additional cost when clinically appropriate

The Nuvella HRT program starts at $197 per month, or $540 when you prepay for the full 90-day program. Regardless of which payment path you choose, you receive your full 90 days of medication upfront.

No hidden fees. No surprise charges. No membership dues. What you see is what you pay.

The Nuvella HRT Starter Kit includes up to four clinician-selected therapies, personalized to your symptoms and health profile:

• Estradiol Cream: Bioidentical estrogen applied to the skin to help relieve hot flashes, night sweats, mood changes, and low energy.
• Progesterone Capsules: A bioidentical hormone taken orally at bedtime that supports restful sleep, mood stability, and uterine health.
• Vaginal Estradiol: Localized estrogen therapy that addresses vaginal dryness and intimate discomfort.
• DHEA: A naturally occurring hormone precursor that supports energy, mood, and cognitive clarity.

Your provider will determine which combination is right for you based on your consultation. Not every woman receives all four. Your protocol is built around what your body needs, and it evolves as you progress through the program.

All medications are compounded at fully licensed U.S. pharmacies and third-party tested for purity, potency, and quality.

Nuvella is a cash-pay program. We do not bill insurance directly. However, we do accept HSA (Health Savings Account) and FSA (Flexible Spending Account) payments, which allow you to use pre-tax dollars toward your care. Many of our patients find this makes the program even more accessible.

We can provide receipts and documentation for reimbursement purposes if needed.

One of the reasons we operate as a cash-pay program is to remove the gatekeeping and delays that often come with insurance-based care. There are no prior authorizations, no formulary restrictions, and no waiting for approval.

Your provider can prescribe what's clinically right for you, and your treatment ships within one business day of approval.

Yes. You do not need to be in full menopause to benefit from hormone therapy.

Perimenopause, the transitional phase leading up to menopause, can begin years before your periods actually stop. During this time, your hormone levels fluctuate significantly, which is what drives many of the symptoms women experience in their late 30s and 40s: irregular cycles, sleep disruption, mood changes, brain fog, hot flashes, weight shifts, and fatigue.

Many women are told by their doctors that they're "too young" for menopause or that their symptoms are "just stress." The reality is that perimenopause is one of the most under-recognized and under-treated phases of a woman's health. If your symptoms are disrupting your quality of life, you deserve to have them evaluated and addressed, regardless of whether you're still menstruating.

Your Nuvella provider will take your cycle status into account when designing your personalized protocol. Treatment plans for perimenopausal women may differ from those for women who are fully postmenopausal, and your provider will explain what to expect based on where you are in the transition.

Yes, and it's actually encouraged.

Emerging clinical research shows that women who combine hormone therapy with GLP-1 weight loss medications experience significantly greater results than those using either treatment alone. One recent study found that postmenopausal women on both HRT and a GLP-1 medication achieved meaningfully more weight loss at every checkpoint over 12 months compared to GLP-1 alone. HRT helps address the hormonal root of metabolic disruption during menopause, while GLP-1 medications target appetite regulation and insulin sensitivity. Together, they work on both sides of the problem.

Through your Nuvella care team, you can access competitive pricing and comprehensive GLP-1 weight loss programs, as well as other longevity and wellness therapies including NAD+ and peptide protocols. Your provider can help you determine which combination is right for your goals.

This is part of what makes Nuvella different. We're not just an HRT prescription service. We're building a complete midlife wellness platform for women, starting with hormone health and expanding into the full range of care that women 40 and older actually need.

You can reach our friendly support team by emailing [email protected] or calling us at (888) 696-7176. For faster service, visit our Patient Services page to submit a message, request a refill, or check your order status. You can also reach us directly through the patient portal. We're here to help!